MR imaging techniques for nano-pathophysiology and theranostics

Kevin M. Bennett, Jun Ichiro Jo, Horacio Cabral, Rumiana Bakalova, Ichio Aoki

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

The advent of nanoparticle DDSs (drug delivery systems, nano-DDSs) is opening new pathways to understanding physiology and pathophysiology at the nanometer scale. A nano-DDS can be used to deliver higher local concentrations of drugs to a target region and magnify therapeutic effects. However, interstitial cells or fibrosis in intractable tumors, as occurs in pancreatic or scirrhous stomach cancer, tend to impede nanoparticle delivery. Thus, it is critical to optimize the type and size of nanoparticles to reach the target. High-resolution 3D imaging provides a means of "seeing" the nanoparticle distribution and therapeutic effects. We introduce the concept of "nano-pathophysiological imaging" as a strategy for theranostics. The strategy consists of selecting an appropriate nano-DDS and rapidly evaluating drug effects in vivo to guide the next round of therapy. In this article we classify nano-DDSs by component carrier materials and present an overview of the significance of nano-pathophysiological MRI.

Original languageEnglish
Pages (from-to)75-94
Number of pages20
JournalAdvanced Drug Delivery Reviews
Volume74
DOIs
StatePublished - Jul 30 2014

Keywords

  • Activatable
  • Cancer
  • DDS
  • In vivo imaging
  • MRI
  • Multimodal
  • Nanoparticles
  • Theranostics

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