TY - JOUR
T1 - Moving past proliferation
T2 - New roles for Cdh1-APC in postmitotic neurons
AU - Stegmüller, Judith
AU - Bonni, Azad
N1 - Funding Information:
Supported by an NIH grant (NS051255, to A.B.), the Christopher Reeve Foundation (A.B.) and the Deutsche Forschungsgemeinschaft (J.S.). We thank members of the Bonni laboratory for helpful discussions and critical reading of the manuscript. We apologize to our colleagues whose work has not been cited owing to space limitations.
PY - 2005/11
Y1 - 2005/11
N2 - Nearly ten years after its discovery as a crucial cell-cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC) is making a debut in neurobiology. During the past year, some of the mystery surrounding a potential function for APC in the brain has been unveiled. Recent studies have defined novel roles for APC in the regulation of axonal growth and patterning, as well as in synaptic development and function. With this strong beginning for APC in neurobiology, the months and years to come are likely to bring many more insights into how neuronal APC contributes to biological processes in brain development and disease.
AB - Nearly ten years after its discovery as a crucial cell-cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC) is making a debut in neurobiology. During the past year, some of the mystery surrounding a potential function for APC in the brain has been unveiled. Recent studies have defined novel roles for APC in the regulation of axonal growth and patterning, as well as in synaptic development and function. With this strong beginning for APC in neurobiology, the months and years to come are likely to bring many more insights into how neuronal APC contributes to biological processes in brain development and disease.
UR - http://www.scopus.com/inward/record.url?scp=26944445014&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2005.09.003
DO - 10.1016/j.tins.2005.09.003
M3 - Review article
C2 - 16168498
AN - SCOPUS:26944445014
SN - 0166-2236
VL - 28
SP - 596
EP - 601
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 11
ER -