Moving known libraries to an addressable array: A site-selective hetero-Michael reaction

Melissae Stuart; Karl Maurer; Kevin D. Moeller

doi:10.1021/bc800025z

Moving known libraries to an addressable array: A site-selective hetero-Michael reaction

Melissae Stuart, Karl Maurer, Kevin D. Moeller

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A two-step, Michael reaction-based strategy for site-selectively placing molecules by unique electrodes in an addressable microelectrode array has been developed. The strategy is compatible with the use of polypeptide nucleophiles and works with microelectrode arrays having either 1024 electrodes/cm ² or 12 544 electrodes/cm². The chemistry should allow for the transfer of existing molecular libraries to microelectrode array devices for analysis.

Original language	English
Pages (from-to)	1514-1517
Number of pages	4
Journal	Bioconjugate Chemistry
Volume	19
Issue number	8
DOIs	https://doi.org/10.1021/bc800025z
State	Published - Aug 2008

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10.1021/bc800025z

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abstract = "A two-step, Michael reaction-based strategy for site-selectively placing molecules by unique electrodes in an addressable microelectrode array has been developed. The strategy is compatible with the use of polypeptide nucleophiles and works with microelectrode arrays having either 1024 electrodes/cm 2 or 12 544 electrodes/cm2. The chemistry should allow for the transfer of existing molecular libraries to microelectrode array devices for analysis.",

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Moving known libraries to an addressable array: A site-selective hetero-Michael reaction

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