TY - JOUR
T1 - Moving in and renovating
T2 - Exporting proteins from Plasmodium into host erythrocytes
AU - Goldberg, Daniel E.
AU - Cowman, Alan F.
N1 - Funding Information:
The authors are supported, in part, by a grant to D.E.G. from the US National Institutes of Health (grant AI047798) and by grants to A.F.C. from the Australian National Health and Medical Research Council.
PY - 2010/9
Y1 - 2010/9
N2 - Malaria parasites live within erythrocytes in the host bloodstream and induce crucial changes to these cells. By so doing, they can obtain the nutrients that they require for growth and can effect the evasion and perturbation of host defences. In order to accomplish this extensive host cell remodelling, the intracellular parasite exports hundreds of proteins to commandeer the erythrocyte for its own purposes. An export motif, a processing enzyme that specifies protein targeting and a translocon that mediates the export of proteins from the parasite into the host erythrocyte have been identified. However, important questions remain regarding the secretory pathway and the function of the translocon. In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite.
AB - Malaria parasites live within erythrocytes in the host bloodstream and induce crucial changes to these cells. By so doing, they can obtain the nutrients that they require for growth and can effect the evasion and perturbation of host defences. In order to accomplish this extensive host cell remodelling, the intracellular parasite exports hundreds of proteins to commandeer the erythrocyte for its own purposes. An export motif, a processing enzyme that specifies protein targeting and a translocon that mediates the export of proteins from the parasite into the host erythrocyte have been identified. However, important questions remain regarding the secretory pathway and the function of the translocon. In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite.
UR - http://www.scopus.com/inward/record.url?scp=77955596444&partnerID=8YFLogxK
U2 - 10.1038/nrmicro2420
DO - 10.1038/nrmicro2420
M3 - Review article
C2 - 20706280
AN - SCOPUS:77955596444
VL - 8
SP - 617
EP - 621
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 9
ER -