@inbook{4ad6f8c23b524bebbc13efe041dbd288,
title = "Mouse and other rodent models of C to U RNA editing",
abstract = "Substitutional RNA editing represents an important posttranscriptional enzymatic pathway for increasing genetic plasticity by permitting production of different translation products from a single genomically encoded template. One of the best-characterized examples in mammals is C to U deamination of the nuclear apolipoprotein B (apoB) mRNA. ApoB mRNA undergoes a single, site-specific cytidine deamination event yielding an edited transcript that results in tissue-specific translation of two distinct isoforms, referred to as apoB100 and apoB48. Tissue- and site-specific cytidine deamination of apoB mRNA is mediated by an incompletely characterized holoenzyme containing a minimal core complex consisting of an RNA-specific cytidine deaminase, Apobec-1 and a requisite cofactor, apobec-1 complementation factor (ACF). The underlying biochemical and genetic mechanisms regulating tissue-specific apoB mRNA editing have been accelerated through development and characterization of physiological rodent models as well as knockout and transgenic animal strains.",
keywords = "Apobec-1, Diet, Hepatocytes, Hormonal regulation, Lipid metabolism, Primer extension, RNA editing, Subcellular distribution",
author = "Valerie Blanc and Davidson, {Nicholas O.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC 2011.",
year = "2011",
doi = "10.1007/978-1-61779-018-8_7",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "121--135",
booktitle = "Methods in Molecular Biology",
}