TY - JOUR
T1 - Mouse and human macrophages and their roles in cardiovascular health and disease
AU - Gallerand, Alexandre
AU - Han, Jichang
AU - Ivanov, Stoyan
AU - Randolph, Gwendalyn J.
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2024/12
Y1 - 2024/12
N2 - The past 15 years have witnessed a leap in understanding the life cycle, gene expression profiles, origins and functions of mouse macrophages in many tissues, including macrophages of the artery wall and heart that have critical roles in cardiovascular health. Here, we review the phenotypical and functional diversity of macrophage populations in multiple organs and discuss the roles that proliferation, survival, and recruitment and replenishment from monocytes have in maintaining macrophages in homeostasis and inflammatory states such as atherosclerosis and myocardial infarction. We also introduce emerging data that better characterize the life cycle and phenotypic profiles of human macrophages. We discuss the similarities and differences between murine and human macrophages, raising the possibility that tissue-resident macrophages in humans may rely more on bone marrow-derived monocytes than in mouse.
AB - The past 15 years have witnessed a leap in understanding the life cycle, gene expression profiles, origins and functions of mouse macrophages in many tissues, including macrophages of the artery wall and heart that have critical roles in cardiovascular health. Here, we review the phenotypical and functional diversity of macrophage populations in multiple organs and discuss the roles that proliferation, survival, and recruitment and replenishment from monocytes have in maintaining macrophages in homeostasis and inflammatory states such as atherosclerosis and myocardial infarction. We also introduce emerging data that better characterize the life cycle and phenotypic profiles of human macrophages. We discuss the similarities and differences between murine and human macrophages, raising the possibility that tissue-resident macrophages in humans may rely more on bone marrow-derived monocytes than in mouse.
UR - http://www.scopus.com/inward/record.url?scp=85210517954&partnerID=8YFLogxK
U2 - 10.1038/s44161-024-00580-3
DO - 10.1038/s44161-024-00580-3
M3 - Review article
C2 - 39604762
AN - SCOPUS:85210517954
SN - 2731-0590
VL - 3
SP - 1424
EP - 1437
JO - Nature Cardiovascular Research
JF - Nature Cardiovascular Research
IS - 12
M1 - ncomms11852
ER -