Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children

Tammy S. Jacobs; Erick Forno; John M. Brehm; Edna Acosta-Pérez; Yueh Ying Han; Joshua Blatter; Peter Thorne; Nervana Metwali; Angel Colón-Semidey; María Alvarez; Glorisa Canino; Juan C. Celedón

doi:10.1016/j.anai.2014.09.007

Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children

Tammy S. Jacobs, Erick Forno, John M. Brehm, Edna Acosta-Pérez, Yueh Ying Han, Joshua Blatter, Peter Thorne, Nervana Metwali, Angel Colón-Semidey, María Alvarez, Glorisa Canino, Juan C. Celedón

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background Little is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).

Objective To evaluate the association between mouse allergen exposure and AR in children.

Methods We examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.

Results In the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P <.001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).

Conclusion Mouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.

Original language	English
Pages (from-to)	614-618.e2
Journal	Annals of Allergy, Asthma and Immunology
Volume	113
Issue number	6
DOIs	https://doi.org/10.1016/j.anai.2014.09.007
State	Published - Dec 1 2014

Access to Document

10.1016/j.anai.2014.09.007

Cite this

Jacobs, T. S., Forno, E., Brehm, J. M., Acosta-Pérez, E., Han, Y. Y., Blatter, J., Thorne, P., Metwali, N., Colón-Semidey, A., Alvarez, M., Canino, G., & Celedón, J. C. (2014). Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children. Annals of Allergy, Asthma and Immunology, 113(6), 614-618.e2. https://doi.org/10.1016/j.anai.2014.09.007

@article{05edb154f1d747bbb23616ff1b35ac2b,

title = "Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children",

abstract = "Background Little is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).Objective To evaluate the association between mouse allergen exposure and AR in children.Methods We examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.Results In the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P <.001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).Conclusion Mouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.",

author = "Jacobs, {Tammy S.} and Erick Forno and Brehm, {John M.} and Edna Acosta-P{\'e}rez and Han, {Yueh Ying} and Joshua Blatter and Peter Thorne and Nervana Metwali and Angel Col{\'o}n-Semidey and Mar{\'i}a Alvarez and Glorisa Canino and Celed{\'o}n, {Juan C.}",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.anai.2014.09.007",

language = "English",

volume = "113",

pages = "614--618.e2",

journal = "Annals of Allergy, Asthma and Immunology",

issn = "1081-1206",

number = "6",

}

TY - JOUR

T1 - Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children

AU - Jacobs, Tammy S.

AU - Forno, Erick

AU - Brehm, John M.

AU - Acosta-Pérez, Edna

AU - Han, Yueh Ying

AU - Blatter, Joshua

AU - Thorne, Peter

AU - Metwali, Nervana

AU - Colón-Semidey, Angel

AU - Alvarez, María

AU - Canino, Glorisa

AU - Celedón, Juan C.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background Little is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).Objective To evaluate the association between mouse allergen exposure and AR in children.Methods We examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.Results In the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P <.001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).Conclusion Mouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.

AB - Background Little is known about exposure to mouse allergen (Mus m 1) and allergic rhinitis (AR).Objective To evaluate the association between mouse allergen exposure and AR in children.Methods We examined the relation between mouse allergen level in house dust and AR in 511 children aged 6 to 14 years in San Juan, Puerto Rico. Study participants were chosen from randomly selected households using a multistage probability sample design. The study protocol included questionnaires, allergy skin testing, and collection of blood and dust samples. AR was defined as current rhinitis symptoms and skin test reactivity to at least one allergen.Results In the multivariate analyses, mouse allergen level was associated with a 25% decreased odds of AR in participating children (95% confidence interval, 0.62-0.92). Although endotoxin and mouse allergen levels were significantly correlated (r = 0.184, P <.001), the observed inverse association between Mus m 1 and AR was not explained by levels of endotoxin or other markers of microbial or fungal exposure (peptidoglycan and glucan).Conclusion Mouse allergen exposure is associated with decreased odds of AR in Puerto Rican school-aged children.

UR - http://www.scopus.com/inward/record.url?scp=84919842294&partnerID=8YFLogxK

U2 - 10.1016/j.anai.2014.09.007

DO - 10.1016/j.anai.2014.09.007

M3 - Article

C2 - 25304339

AN - SCOPUS:84919842294

SN - 1081-1206

VL - 113

SP - 614-618.e2

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

IS - 6

ER -

Mouse allergen exposure and decreased risk of allergic rhinitis in school-aged children

Abstract

Access to Document

Other files and links

Fingerprint

Cite this