Motor nerve sprouting and acetylcholine receptors

Alan Pestronk, Daniel B. Drachman

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with α-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.

Original languageEnglish
Pages (from-to)1223-1225
Number of pages3
JournalScience
Volume199
Issue number4334
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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