Moss PIEZO homologs have a conserved structure, are ubiquitously expressed, and do not affect general vacuole function

Ivan Radin, Ryan A. Richardson, Elizabeth S. Haswell

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The PIEZO protein family was first described in animals where these mechanosensitive calcium channels perform numerous essential functions, including the perception of light touch, shear, and compressive forces. PIEZO homologs are present in most eukaryotic lineages and recently we reported that two PIEZO homologs from moss Physcomitrium patens localize to the vacuolar membrane and modulate its morphology in tip-growing caulonemal cells. Here we show that predicted structures of both PpPIEZO1 and PpPIEZO2 are very similar to that of mouse Piezo2. Furthermore, we show that both moss PIEZO genes are ubiquitously expressed in moss vegetative tissues and that they are not required for normal vacuolar pH or intracellular osmotic potential. These results suggest that moss PIEZO proteins are widely expressed mechanosensory calcium channels that serve a signaling rather than maintenance role in vacuoles.

Original languageEnglish
Article number2015893
JournalPlant Signaling and Behavior
Volume17
Issue number1
DOIs
StatePublished - 2022

Keywords

  • PIEZO
  • Physcomitrium
  • mechanosensitive ion channel
  • moss
  • vacuole

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