TY - JOUR
T1 - Morphometry-based measurements of the structural response to whole-brain radiation
AU - Fuentes, D.
AU - Contreras, J.
AU - Yu, J.
AU - He, R.
AU - Castillo, E.
AU - Castillo, R.
AU - Guerrero, T.
N1 - Funding Information:
This work is supported in part by the O’Donnell Foundation and NIH DP2OD007044, NIH DP2OD007044-01S1, and CPRIT RP101502 funding mechanisms. The authors would also like to thank the open source communities ITK, ANTs [], itk-SNAP [], and FSL [] for providing enabling software for image processing and visualization.
Publisher Copyright:
© 2014, CARS.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.
AB - Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.
KW - Computational anatomy
KW - Diffeomorphism
KW - Image registration
KW - Morphometry
KW - Radiation therapy response
UR - http://www.scopus.com/inward/record.url?scp=84939975841&partnerID=8YFLogxK
U2 - 10.1007/s11548-014-1128-3
DO - 10.1007/s11548-014-1128-3
M3 - Article
C2 - 25408306
AN - SCOPUS:84939975841
SN - 1861-6410
VL - 10
SP - 393
EP - 401
JO - International Journal of Computer Assisted Radiology and Surgery
JF - International Journal of Computer Assisted Radiology and Surgery
IS - 4
ER -