Morphologic Features of Conventional Squamous Cell Carcinoma of the Oropharynx: 'Keratinizing' and 'Nonkeratinizing' Histologic Types as the Basis for a Consistent Classification System

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Morphologic assessment is one of the most basic tools that pathologists use to classify tumors. Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx has unique morphologic features that can be readily recognized under the microscope. Yet, these features are not widely recognized or uniformly reported. In our practice, we group oropharyngeal squamous cell carcinomas into 'nonkeratinizing', 'nonkeratinizing with maturation', and 'keratinizing' histologic types. The 'nonkeratinizing' type has a very strong association with HPV, while the 'keratinizing' type has a weaker association with the virus. 'Nonkeratinizing with maturation' is intermediate but much more closely related to the 'nonkeratinizing' type. This classification system parallels that of sinonasal and nasopharyngeal squamous cell carcinomas where nonkeratinizing squamous cell carcinomas are widely recognized histologic variants. This review will discuss this classification system and its utility in routine clinical practice.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalHead and Neck Pathology
Volume6
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 3 2012

Keywords

  • Human papillomavirus
  • Morphology
  • Nonkeratinizing squamous cell carcinoma
  • Oropharynx

Fingerprint

Dive into the research topics of 'Morphologic Features of Conventional Squamous Cell Carcinoma of the Oropharynx: 'Keratinizing' and 'Nonkeratinizing' Histologic Types as the Basis for a Consistent Classification System'. Together they form a unique fingerprint.

Cite this