Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial

Sapna S. Gangaputra; Michael M. Altaweel; Qian Peng; David S. Friedman; P. Kumar Rao; C. Stephen Foster; Rosa Y. Kim; Susan B. Reed; Sunil K. Srivastava; Ira G. Wong; John H. Kempen

doi:10.3109/09273948.2011.583376

Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial

Sapna S. Gangaputra, Michael M. Altaweel, Qian Peng, David S. Friedman, P. Kumar Rao, C. Stephen Foster, Rosa Y. Kim, Susan B. Reed, Sunil K. Srivastava, Ira G. Wong, John H. Kempen

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Purpose: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial. Methods: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images. Results: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ=.34). Intergrader reproducibility at the RC was better (weighted κ=.59, ICC 0.74). Conclusion: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.

Original language	English
Pages (from-to)	267-274
Number of pages	8
Journal	Ocular Immunology and Inflammation
Volume	19
Issue number	4
DOIs	https://doi.org/10.3109/09273948.2011.583376
State	Published - Aug 2011

Keywords

clinical trial
glaucoma
optic nerve head
uveitis

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10.3109/09273948.2011.583376

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@article{e70ae42bb11744d1804bd7a5a4a65a7e,

title = "Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial",

abstract = "Purpose: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial. Methods: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images. Results: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ=.34). Intergrader reproducibility at the RC was better (weighted κ=.59, ICC 0.74). Conclusion: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.",

keywords = "clinical trial, glaucoma, optic nerve head, uveitis",

author = "Gangaputra, {Sapna S.} and Altaweel, {Michael M.} and Qian Peng and Friedman, {David S.} and Rao, {P. Kumar} and Foster, {C. Stephen} and Kim, {Rosa Y.} and Reed, {Susan B.} and Srivastava, {Sunil K.} and Wong, {Ira G.} and Kempen, {John H.}",

note = "Funding Information: This work was supported by cooperative agreements from the National Eye Institute to Mount Sinai School of Medicine (U10 EY 014655), The Johns Hopkins University Bloomberg School of Public Health (U10 EY 014660), and the University of Wisconsin, Madison, School of Medicine (U10 EY 014656).",

year = "2011",

month = aug,

doi = "10.3109/09273948.2011.583376",

language = "English",

volume = "19",

pages = "267--274",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

number = "4",

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T1 - Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial

AU - Gangaputra, Sapna S.

AU - Altaweel, Michael M.

AU - Peng, Qian

AU - Friedman, David S.

AU - Rao, P. Kumar

AU - Foster, C. Stephen

AU - Kim, Rosa Y.

AU - Reed, Susan B.

AU - Srivastava, Sunil K.

AU - Wong, Ira G.

AU - Kempen, John H.

N1 - Funding Information: This work was supported by cooperative agreements from the National Eye Institute to Mount Sinai School of Medicine (U10 EY 014655), The Johns Hopkins University Bloomberg School of Public Health (U10 EY 014660), and the University of Wisconsin, Madison, School of Medicine (U10 EY 014656).

PY - 2011/8

Y1 - 2011/8

N2 - Purpose: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial. Methods: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images. Results: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ=.34). Intergrader reproducibility at the RC was better (weighted κ=.59, ICC 0.74). Conclusion: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.

AB - Purpose: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial. Methods: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images. Results: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ=.34). Intergrader reproducibility at the RC was better (weighted κ=.59, ICC 0.74). Conclusion: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.

KW - clinical trial

KW - glaucoma

KW - optic nerve head

KW - uveitis

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Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial

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