Morphine inhibits N-methyl-D,L-aspartic acid-induced luteinizing hormone release in vivo

B. A. Schainker, T. J. Cicero

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Abstract

In an attempt to examine whether morphine acts at the level of the hypothalamus in vivo to inhibit the elaboration of luteinizing hormone (LH), we employed a potent neuroexcitatory amino acid, N-methyl-D,L-aspartic acid (NMA), that has been shown to acutely elevate serum LH in the male rat by apparently enhancing the release of LH releasing hormone (LHRH) at the level of the hypothalamus. Morphine pretreatment shifted the NMA dose response curve to the right and morphine's inhibition of the NMA-induced response was reversed by concurrent naloxone administration. Since neither NMA nor morphine affect pituitary release of LH in vivo or in vitro, the results appear to provide the first direct in vivo support for the assertion that morphine acts at a suprasellar locus to depress the elaboration of LH.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalResearch Communications in Substances of Abuse
Volume1
Issue number3
StatePublished - Jan 1 1980

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