More on Maternal Serum Alpha-Fetoprotein: Problems with a Test Kit

Linda A. Bradley, Frederick Hecht, Roland Valdes, Gerald Kessler, James P. Crane, Richard H. Turner, Charles Bowden

    Research output: Contribution to journalLetterpeer-review


    To the Editor: A potentially serious problem with the performance of the Kallestad alpha-fetoprotein kit has been reported by Knight et al. (Feb. 20 issue).1 We tested 3563 second-trimester serum samples for alpha-fetoprotein, using the Kallestad kit. Median values for each gestational week were established in our laboratory, and results on routine quality-control procedures for the assay were consistently within normal limits. We found that the distribution of values was strongly skewed to the low end, with 17.5 percent falling below 0.5 multiples of the median and 11.1 percent falling below 0.4 multiples of the median. Our results were in.

    Original languageEnglish
    Pages (from-to)193-195
    Number of pages3
    JournalNew England Journal of Medicine
    Issue number3
    StatePublished - Jul 17 1986


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