Mood changes with methotrexate therapy for dermatologic disease

Trisha Bhat; Carrie C. Coughlin

doi:10.1111/pde.13406

Mood changes with methotrexate therapy for dermatologic disease

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Abstract

Neurotoxicity and cognitive effects of low-dose methotrexate for rheumatologic disease have often been described, but the neuropsychiatric effects of low-dose methotrexate for cutaneous disease have been underreported in the dermatology literature. We describe two children who experienced mood changes with methotrexate treatment for lichen sclerosus with morphea overlap and psoriasis, with rapid resolution of these symptoms after methotrexate cessation. We also detail possible mechanisms underlying psychiatric changes with methotrexate therapy.

Original language	English
Pages (from-to)	253-254
Number of pages	2
Journal	Pediatric Dermatology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1111/pde.13406
State	Published - Mar 1 2018

Keywords

drug reaction
inflammatory disorders
pharmacology
psoriasis
systemic
therapy

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AB - Neurotoxicity and cognitive effects of low-dose methotrexate for rheumatologic disease have often been described, but the neuropsychiatric effects of low-dose methotrexate for cutaneous disease have been underreported in the dermatology literature. We describe two children who experienced mood changes with methotrexate treatment for lichen sclerosus with morphea overlap and psoriasis, with rapid resolution of these symptoms after methotrexate cessation. We also detail possible mechanisms underlying psychiatric changes with methotrexate therapy.

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KW - inflammatory disorders

KW - pharmacology

KW - psoriasis

KW - systemic

KW - therapy

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Mood changes with methotrexate therapy for dermatologic disease

Abstract

Keywords

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