Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome

Keyphrases

• Age at Diagnosis 25%
• Age of Onset 25%
• Arthritis 25%
• Autoimmune Hepatitis 25%
• Autoimmunity 100%
• Bone Marrow Transplantation 25%
• Cellular Immunodeficiency 25%
• Clinical Manifestations 25%
• Clinical Symptoms 25%
• Double Negative 25%
• Early Identification 25%
• Early Onset 100%
• Endocrinopathy 25%
• Enteropathy 25%
• Gain-of-function 100%
• Gain-of-function mutation 25%
• Gain-of-function Variant 50%
• Germ Cells 50%
• Growth Delay 25%
• Humoral Immunodeficiency 25%
• Immune Dysregulation 25%
• Immune Thrombocytopenia 50%
• Immune-mediated Diseases 25%
• Immunosuppressive Therapy 25%
• Inclusion Criteria 25%
• International Cohort 25%
• JAK Inhibitors 25%
• Lifesaving 25%
• Lymphoproliferation 100%
• Monogenic 100%
• Multisystem 25%
• Multisystem Disease 25%
• Natural History 100%
• Neurological Diseases 25%
• Overall Survival 50%
• Patient Care 25%
• Prompt Treatment 25%
• Pulmonary Disease 25%
• Renal Disease 25%
• Renal Malignancy 25%
• Signal Transducer and Activator of Transcription 3 25%
• Skin Diseases 25%
• Survival Rate 25%
• Symptom Onset 25%
• T Cells 25%
• Treatment Implementation 25%
• Treatment Modalities 25%
• Treatment Strategy 25%
• Treatment Survival 25%
• Unique mutation 25%
• Vasculopathy 25%

Medicine and Dentistry

• Arthritis 20%
• Autoimmune Hepatitis 20%
• Autoimmunity 100%
• Bone Marrow Transplantation 20%
• Cancer 20%
• Cohort Analysis 20%
• Cytopenia 40%
• Dermatosis 20%
• Diseases 20%
• Endocrine Disease 20%
• Enteropathy 20%
• Gain of Function Mutation 20%
• Germ Cell 40%
• Immune Deficiency 20%
• Immune Dysregulation 20%
• Infection 20%
• Janus Kinase Inhibitor 20%
• Lymphocyte Proliferation 100%
• Nephropathy 20%
• Neurologic Disease 20%
• Onset Age 20%
• Overall Survival 40%
• Patient Care 20%
• Silo-Filler's Disease 20%
• STAT3 Protein 20%
• Survival Rate 20%
• Systemic Disease 20%
• T Cell 20%
• Vascular Disease 20%

Immunology and Microbiology

• Arthritis 16%
• Autoimmune Hepatitis 16%
• Autoimmunity 100%
• Bone Marrow Transplantation 16%
• Gain of Function Mutation 16%
• Germ Cell 33%
• Immune Dysregulation 16%
• Immunodeficiency 16%
• Lymphocyte Proliferation 100%
• Overall Survival 33%
• STAT3 100%
• Survival Rate 16%
• T Cell 16%