TY - JOUR
T1 - Monogenic autoimmunity and infectious diseases
T2 - the double-edged sword of immune dysregulation
AU - Bigley, Tarin M.
AU - Cooper, Megan A.
N1 - Funding Information:
This work was supported by the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies at St. Louis Children's Hospital and the St. Louis Children's Hospital Foundation. Figures 2–4 were created with BioRender.com.
Funding Information:
This work was supported by the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies at St. Louis Children’s Hospital and the St. Louis Children’s Hospital Foundation . Figures 2–4 were created with BioRender.com .
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/10
Y1 - 2021/10
N2 - The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. The SARS-CoV-2 pandemic has highlighted how monogenic autoimmunity can increase risk for serious infection with the discovery of severe disease in patients with pre-existing antibodies to Type I IFNs. This review discusses recent insight into the relationship between monogenic autoimmunity and infectious diseases.
AB - The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. The SARS-CoV-2 pandemic has highlighted how monogenic autoimmunity can increase risk for serious infection with the discovery of severe disease in patients with pre-existing antibodies to Type I IFNs. This review discusses recent insight into the relationship between monogenic autoimmunity and infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=85109918379&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2021.06.013
DO - 10.1016/j.coi.2021.06.013
M3 - Review article
C2 - 34265589
AN - SCOPUS:85109918379
SN - 0952-7915
VL - 72
SP - 230
EP - 238
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -