Monocytes in sterile inflammation: Recruitment and functional consequences

Jessica H. Spahn, Daniel Kreisel

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Monocytes play an important role in initiating innate immune responses. Three subsets of these cells have been defined in mice including classical, nonclassical and intermediate monocytes. Each of these cell types has been extensively studied for their role in infectious diseases. However, their role in sterile injury as occurs during ischemia-reperfusion injury, atherosclerosis, and trauma has only recently been the focus of investigations. Here, we review mechanisms of monocyte recruitment to sites of sterile injury, their modes of action, and their effect on disease outcome in murine models with some references to human studies. Therapeutic strategies to target these cells must be developed with caution since each monocyte subset is capable of mediating either anti- or pro-inflammatory effects depending on the setting.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume62
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • Functional outcome
  • Monocytes
  • Recruitment
  • Sterile inflammation

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