TY - JOUR
T1 - Monocyte trafficking in acute and chronic inflammation
AU - Ingersoll, Molly A.
AU - Platt, Andrew M.
AU - Potteaux, Stephane
AU - Randolph, Gwendalyn J.
N1 - Funding Information:
We acknowledge the researchers who have contributed to this field but whose work is not cited or was cited through review articles because of space limitations. The work of our laboratory is supported by National Institutes of Health grants AI061741, AI049653, and HL096539 to GJR, an American Heart Association Established Investigator Award 0740052 to GJR and a Ruth L. Kirschstein National Research Service Award F32HL096291 to M.A.I.
PY - 2011/10
Y1 - 2011/10
N2 - Environmental signals at the site of inflammation mediate rapid monocyte mobilization and dictate differentiation programs whereby these cells give rise to macrophages or dendritic cells. Monocytes participate in tissue healing, clearance of pathogens and dead cells, and initiation of adaptive immunity. However, recruited monocytes can also contribute to the pathogenesis of infection and chronic inflammatory disease, such as atherosclerosis. Here, we explore monocyte trafficking in the context of acute inflammation, relying predominantly on data from microbial infection models. These mechanisms will be compared to monocyte trafficking during chronic inflammation in experimental models of atherosclerosis. Recent developments suggest that monocyte trafficking shares common themes in diverse inflammatory diseases; however, important differences exist between monocyte migratory pathways in acute and chronic inflammation.
AB - Environmental signals at the site of inflammation mediate rapid monocyte mobilization and dictate differentiation programs whereby these cells give rise to macrophages or dendritic cells. Monocytes participate in tissue healing, clearance of pathogens and dead cells, and initiation of adaptive immunity. However, recruited monocytes can also contribute to the pathogenesis of infection and chronic inflammatory disease, such as atherosclerosis. Here, we explore monocyte trafficking in the context of acute inflammation, relying predominantly on data from microbial infection models. These mechanisms will be compared to monocyte trafficking during chronic inflammation in experimental models of atherosclerosis. Recent developments suggest that monocyte trafficking shares common themes in diverse inflammatory diseases; however, important differences exist between monocyte migratory pathways in acute and chronic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=80053322451&partnerID=8YFLogxK
U2 - 10.1016/j.it.2011.05.001
DO - 10.1016/j.it.2011.05.001
M3 - Review article
C2 - 21664185
AN - SCOPUS:80053322451
SN - 1471-4906
VL - 32
SP - 470
EP - 477
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -