TY - JOUR
T1 - Monocyte differentiation and antigen-presenting functions
AU - Jakubzick, Claudia V.
AU - Randolph, Gwendalyn J.
AU - Henson, Peter M.
N1 - Funding Information:
The authors acknowledge support from the following National Institutes of Health grants: R01HL115334 (to C.V.J.), R37AI049653 (to G.J.R.) and R01HL114381 (to P.M.H.).
Publisher Copyright:
© 017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes of tissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues. In addition, we consider the emerging roles for monocytes in adaptive immunity as antigen-presenting cells.
AB - Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes of tissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues. In addition, we consider the emerging roles for monocytes in adaptive immunity as antigen-presenting cells.
UR - http://www.scopus.com/inward/record.url?scp=85018305787&partnerID=8YFLogxK
U2 - 10.1038/nri.2017.28
DO - 10.1038/nri.2017.28
M3 - Review article
C2 - 28436425
AN - SCOPUS:85018305787
SN - 1474-1733
VL - 17
SP - 349
EP - 362
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 6
ER -