Monoclonal antibodies binding data for SARS-CoV-2 proteins

Nawneet Mishra, Joan Teyra, Ruth Mabel Boytz, Shane Miersch, Trudy N. Merritt, Lia Cardarelli, Maryna Gorelik, Filip Mihalic, Per Jemth, Robert A. Davey, Sachdev S. Sidhu, Daisy W. Leung, Gaya K. Amarasinghe

Research output: Contribution to journalArticlepeer-review

Abstract

SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synthetically developed monoclonal antibodies for the SARS-CoV-2 proteins. The antibodies from phage-displayed antibody libraries were selected with the SARS-CoV-2 proteins immobilized in microwell plates. The clones which bind to the antigen in Fab-phage ELISA were selected, and a two-point competitive phage ELISA was performed. Antibodies binding kinetic of IgGs for SARS-CoV2 proteins further carried with B.L.I. Systematic analysis of binding with different control proteins and purified SARS-CoV-2 ensured the robustness of the antibodies.

Original languageEnglish
Article number108415
JournalData in Brief
Volume43
DOIs
StatePublished - Aug 2022

Keywords

  • B.L.I.
  • ELISA
  • SARS-CoV-2

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