Monocarboxylates (pyruvate and lactate) as alternative energy substrates for the induction of long-term potentiation in rat hippocampal slices

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Abstract

We previously reported that mild hypoglycemic conditions hamper the induction of long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. In the present study, we examined whether monocarboxylates (pyruvate and lactate) permit LTP induction when glucose is unavailable. During glucose deprivation, pyruvate and lactate not only maintained basal synaptic transmission but also allowed LTP induction, with pyruvate being more effective than lactate. Additionally, LTP inhibition by 5 μM iodoacetate, a glycolytic inhibitor, was prevented by addition of pyruvate but not lactate. These results suggest that monocarboxylates can be effective alternative energy substrates for LTP induction when glucose is not available. However, lactate and pyruvate are not identical as energy sources for LTP induction.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Volume232
Issue number1
DOIs
StatePublished - Aug 22 1997

Keywords

  • Alternative energy substrate
  • Glucose deprivation
  • Hippocampus
  • Iodoacetate
  • Lactate
  • Long- term potentiation
  • Monocarboxylate
  • Pyruvate

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