Monoamine oxidases and alcoholism. I. Studies in unrelated alcoholics and normal controls

A. Parsian, B. K. Suarez, B. Tabakoff, P. Hoffman, L. Ovchinnikova, L. Fisher, C. R. Cloninger

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    42 Scopus citations

    Abstract

    Low platelet MAO activity has been associated with alcoholism. In order to evaluate the role of MAO genes in susceptibility to alcoholism, we have taken a biochemical and molecular genetic approach. The sample consisted of 133 alcoholic probands who were classified by subtypes of alcoholism and 92 normal controls. For those subjects typed for platelet MAO activity, alcoholics (N = 74) were found not to differ from the non-alcoholics controls (N = 34). Neither was there a significant difference between type I and type II alcoholics or between either subtype and normal controls. However, we do find significant differences between male and female alcoholics, but not between male and female controls. The allele frequency distribution for the MAO-A and MAO-B dinucleotide repeats is different between the alcoholic sample (N = 133) and the normal control sample (N = 92). In a two-way analysis of variance of MAO-B activity as a function of the allelic variation of each marker locus and diagnosis, there is no evidence for mean differences in activity levels for the different alleles. Our findings do not rule out a role for the MAO-B gene in controlling the enzyme activity because the dinucleotide repeats are located in introns.

    Original languageEnglish
    Pages (from-to)409-416
    Number of pages8
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Volume60
    Issue number5
    DOIs
    StatePublished - Oct 30 1995

    Keywords

    • MAO activity
    • alcoholism
    • association
    • dinucleotide repeats

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    Parsian, A., Suarez, B. K., Tabakoff, B., Hoffman, P., Ovchinnikova, L., Fisher, L., & Cloninger, C. R. (1995). Monoamine oxidases and alcoholism. I. Studies in unrelated alcoholics and normal controls. American Journal of Medical Genetics - Neuropsychiatric Genetics, 60(5), 409-416. https://doi.org/10.1002/ajmg.1320600511