TY - JOUR
T1 - Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP
AU - Latorre-Esteves, Elena
AU - Akilov, Oleg E.
AU - Rai, Prakash
AU - Beverley, Stephen M.
AU - Hasan, Tayyaba
PY - 2010
Y1 - 2010
N2 - A murine model of cutaneous leishmaniasis with green fluorescent protein positive (GFP+ L. major enables the monitoring of parasitic load via measurements of GFP fluorescence intensity, allowing for a faster and more efficient way of monitoring the clinical outcome of photodynamic therapy (PDT). This model may provide new insights on the phototoxic aspects in PDT. Although PDT regimens may be somewhat different in humans, it is expected that the developed model will facilitate the optimization and clinical translation of PDT as a therapy for cutaneous leishmaniasis and the eventual development of topical PDT treatments for other granulomatous infections.
AB - A murine model of cutaneous leishmaniasis with green fluorescent protein positive (GFP+ L. major enables the monitoring of parasitic load via measurements of GFP fluorescence intensity, allowing for a faster and more efficient way of monitoring the clinical outcome of photodynamic therapy (PDT). This model may provide new insights on the phototoxic aspects in PDT. Although PDT regimens may be somewhat different in humans, it is expected that the developed model will facilitate the optimization and clinical translation of PDT as a therapy for cutaneous leishmaniasis and the eventual development of topical PDT treatments for other granulomatous infections.
KW - Green fluorescent protein
KW - Leishmania
KW - Murine model
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=77953951793&partnerID=8YFLogxK
U2 - 10.1002/jbio.201000008
DO - 10.1002/jbio.201000008
M3 - Article
C2 - 20376860
AN - SCOPUS:77953951793
SN - 1864-063X
VL - 3
SP - 328
EP - 335
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 5-6
ER -