An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.
|Number of pages||7|
|Journal||Proceedings of SPIE - The International Society for Optical Engineering|
|State||Published - Jan 1 1999|
|Event||Proceedings of the 1999 Optical Diagnostics of Biological Fluids IV - San Jose, CA, USA|
Duration: Jan 26 1999 → Jan 27 1999