Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

Ghazaleh Ashrafi; Jaime de Juan-Sanz; Ryan J. Farrell; Timothy A. Ryan

doi:10.1016/j.neuron.2019.11.020

Molecular Tuning of the Axonal Mitochondrial Ca²⁺ Uniporter Ensures Metabolic Flexibility of Neurotransmission

Ghazaleh Ashrafi
, Jaime de Juan-Sanz
, Ryan J. Farrell
, Timothy A. Ryan

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Abstract

Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca²⁺ uptake in order to accelerate ATP production.

Original language	English
Pages (from-to)	678-687.e5
Journal	Neuron
Volume	105
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2019.11.020
State	Published - Feb 19 2020

Keywords

ATP
Ca2+ imaging
MCU
MICU3
metabolic flexibility
metabolism
mitochondria
spiking HEK cells
synapse
synaptic transmission

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10.1016/j.neuron.2019.11.020

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title = "Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission",

abstract = "Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca2+ uptake in order to accelerate ATP production.",

keywords = "ATP, Ca2+ imaging, MCU, MICU3, metabolic flexibility, metabolism, mitochondria, spiking HEK cells, synapse, synaptic transmission",

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AU - Ryan, Timothy A.

PY - 2020/2/19

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KW - metabolic flexibility

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KW - mitochondria

KW - spiking HEK cells

KW - synapse

KW - synaptic transmission

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Molecular Tuning of the Axonal Mitochondrial Ca²⁺ Uniporter Ensures Metabolic Flexibility of Neurotransmission

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Keywords

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