@article{c8ccab80a0e84b119441851bea030639,
title = "Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission",
abstract = "Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca2+ uptake in order to accelerate ATP production.",
keywords = "ATP, Ca2+ imaging, MCU, MICU3, metabolic flexibility, metabolism, mitochondria, spiking HEK cells, synapse, synaptic transmission",
author = "Ghazaleh Ashrafi and {de Juan-Sanz}, Jaime and Farrell, {Ryan J.} and Ryan, {Timothy A.}",
note = "Funding Information: We thank members of the Ryan lab for frequent discussions about this work and Adam Cohen (Harvard University) for generously providing the “spiking” HEK cells. This work was supported by the NIH ( NS036942 and MH085783 to T.A.R.). Funding Information: We thank members of the Ryan lab for frequent discussions about this work and Adam Cohen (Harvard University) for generously providing the ?spiking? HEK cells. This work was supported by the NIH (NS036942 and MH085783 to T.A.R.). Conceptualization, G.A. J.d.J.-S. and T.A.R.; Investigation, G.A. J.d.J.-S. and R.J.F.; Writing ? Original Draft, G.A. J.d.J.-S. and T.A.R.; Writing ? Review & Editing, G.A. J.d.J.-S. R.J.F. and T.A.R.; Visualization, G.A. J.d.J.-S. and R.J.F.; Funding Acquisition, T.A.R.; Supervision, T.A.R. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = feb,
day = "19",
doi = "10.1016/j.neuron.2019.11.020",
language = "English",
volume = "105",
pages = "678--687.e5",
journal = "Neuron",
issn = "0896-6273",
number = "4",
}