Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

Ghazaleh Ashrafi, Jaime de Juan-Sanz, Ryan J. Farrell, Timothy A. Ryan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca2+ uptake in order to accelerate ATP production.

Original languageEnglish
Pages (from-to)678-687.e5
JournalNeuron
Volume105
Issue number4
DOIs
StatePublished - Feb 19 2020
Externally publishedYes

Keywords

  • ATP
  • Ca2+ imaging
  • MCU
  • metabolic flexibility
  • metabolism
  • MICU3
  • mitochondria
  • spiking HEK cells
  • synapse
  • synaptic transmission

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