Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

Ghazaleh Ashrafi; Jaime de Juan-Sanz; Ryan J. Farrell; Timothy A. Ryan

doi:10.1016/j.neuron.2019.11.020

Molecular Tuning of the Axonal Mitochondrial Ca²⁺ Uniporter Ensures Metabolic Flexibility of Neurotransmission

Ghazaleh Ashrafi, Jaime de Juan-Sanz, Ryan J. Farrell, Timothy A. Ryan

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca²⁺ uptake in order to accelerate ATP production.

Original language	English
Pages (from-to)	678-687.e5
Journal	Neuron
Volume	105
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2019.11.020
State	Published - Feb 19 2020
Externally published	Yes

Keywords

ATP
Ca2+ imaging
MCU
metabolic flexibility
metabolism
MICU3
mitochondria
spiking HEK cells
synapse
synaptic transmission

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10.1016/j.neuron.2019.11.020

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Ashrafi, G., de Juan-Sanz, J., Farrell, R. J., & Ryan, T. A. (2020). Molecular Tuning of the Axonal Mitochondrial Ca²⁺ Uniporter Ensures Metabolic Flexibility of Neurotransmission. Neuron, 105(4), 678-687.e5. https://doi.org/10.1016/j.neuron.2019.11.020

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