Abstract
Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca2+ uptake in order to accelerate ATP production.
Original language | English |
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Pages (from-to) | 678-687.e5 |
Journal | Neuron |
Volume | 105 |
Issue number | 4 |
DOIs | |
State | Published - Feb 19 2020 |
Keywords
- ATP
- Ca2+ imaging
- MCU
- MICU3
- metabolic flexibility
- metabolism
- mitochondria
- spiking HEK cells
- synapse
- synaptic transmission