Molecular targets to overcome radioresistance

Ralph R. Weichselbaum; Michael A. Beckett; Dennis E. Hallahan; Donald W. Kufe; Everett E. Vokes

Molecular targets to overcome radioresistance

Ralph R. Weichselbaum, Michael A. Beckett, Dennis E. Hallahan, Donald W. Kufe, Everett E. Vokes

Research output: Contribution to journal › Article › peer-review

Abstract

Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.

Original language	English
Pages (from-to)	14-20
Number of pages	7
Journal	Seminars in Oncology
Volume	19
Issue number	4 SUPPL. 11
State	Published - Aug 1992

Cite this

@article{7c334a0dbedd4255b2e9da1e806d7a03,

title = "Molecular targets to overcome radioresistance",

abstract = "Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.",

author = "Weichselbaum, {Ralph R.} and Beckett, {Michael A.} and Hallahan, {Dennis E.} and Kufe, {Donald W.} and Vokes, {Everett E.}",

year = "1992",

month = aug,

language = "English",

volume = "19",

pages = "14--20",

journal = "Seminars in Oncology",

issn = "0093-7754",

number = "4 SUPPL. 11",

}

TY - JOUR

T1 - Molecular targets to overcome radioresistance

AU - Weichselbaum, Ralph R.

AU - Beckett, Michael A.

AU - Hallahan, Dennis E.

AU - Kufe, Donald W.

AU - Vokes, Everett E.

PY - 1992/8

Y1 - 1992/8

N2 - Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.

AB - Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.

UR - http://www.scopus.com/inward/record.url?scp=0026776117&partnerID=8YFLogxK

M3 - Article

C2 - 1509276

AN - SCOPUS:0026776117

SN - 0093-7754

VL - 19

SP - 14

EP - 20

JO - Seminars in Oncology

JF - Seminars in Oncology

IS - 4 SUPPL. 11

ER -

Molecular targets to overcome radioresistance

Abstract

Other files and links

Fingerprint

Cite this