Molecular targets to overcome radioresistance

Ralph R. Weichselbaum, Michael A. Beckett, Dennis E. Hallahan, Donald W. Kufe, Everett E. Vokes

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalSeminars in Oncology
Volume19
Issue number4 SUPPL. 11
StatePublished - Aug 1992

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