This chapter discusses prosurvival signal transduction pathways, such as PI3K/Akt and MAPK/ERK signaling, induced by ionizing radiation in the tumor microvasculature. Molecular targeting of these radiation-induced signaling pathways provides a means to enhance tumor control. Preclinical studies show that this approach improves the efficacy of radiotherapy in mouse models of cancer.
|Title of host publication||Molecular Determinants of Radiation Response|
|Number of pages||14|
|State||Published - Dec 1 2011|
|Name||Current Cancer Research|
- Molecular targeting
- Signal transduction pathways