Abstract

This chapter discusses prosurvival signal transduction pathways, such as PI3K/Akt and MAPK/ERK signaling, induced by ionizing radiation in the tumor microvasculature. Molecular targeting of these radiation-induced signaling pathways provides a means to enhance tumor control. Preclinical studies show that this approach improves the efficacy of radiotherapy in mouse models of cancer.

Original languageEnglish
Title of host publicationMolecular Determinants of Radiation Response
EditorsTheodore DeWeese
Pages187-200
Number of pages14
DOIs
StatePublished - Dec 1 2011

Publication series

NameCurrent Cancer Research
Volume19
ISSN (Print)0940-0745

Keywords

  • Molecular targeting
  • Radiotherapy
  • Signal transduction pathways

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