TY - CHAP
T1 - Molecular Regulation, Evolutionary, and Functional Adaptations Associated with C to U Editing of Mammalian ApolipoproteinB mRNA
AU - Anant, Shrikant
AU - Blanc, Valerie
AU - Davidson, Nicholas O.
N1 - Funding Information:
Work cited from the authors' laboratories is supported by the National Institutes of Health grants DK-56260 and HL-38180 to NOD, DK-62265 to S.A., and the Digestive Disease Research Core Center Grant DK-52574. S.A. is a Research Scholar of the American Gastroenterology Association. The authors acknowledge valuable discussions with current and former laboratory members, particularly Jeff Henderson, Susan Kennedy, Debnath Mukhophadyay, and Libby Newberry.
PY - 2003
Y1 - 2003
N2 - RNA editing encompasses an important class of co- or posttranscriptional nucleic acid modification that has expanded our understanding of the range of mechanisms that facilitate genetic plasticity. Since the initial description of RNA editing in trypanosome mitochondria, a model of gene regulation has emerged that now encompasses a diverse range of biochemical and genetic mechanisms by which nuclear, mitochondrial, and t-RNA sequences are modified from templated versions encoded in the genome. RNA editing is genetically and biochemically distinct from other RNA modifications such as splicing, capping, and polyadenylation although, as discussed in Section I, these modifications may have relevance to the regulation of certain types of mammalian RNA editing. This review will focus on C to U RNA editing, in particular, the biochemical and genetic mechanisms that regulate this process in mammals. These mechanisms will be examined in the context of the prototype model of C to U RNA editing, namely the posttranscriptional cytidine deamination targeting a single nucleotide in mammalian apolipoproteinB (apoB). Other examples of C to U RNA editing will be discussed and the molecular mechanisms-where known-contrasted with those regulating apoB RNA editing.
AB - RNA editing encompasses an important class of co- or posttranscriptional nucleic acid modification that has expanded our understanding of the range of mechanisms that facilitate genetic plasticity. Since the initial description of RNA editing in trypanosome mitochondria, a model of gene regulation has emerged that now encompasses a diverse range of biochemical and genetic mechanisms by which nuclear, mitochondrial, and t-RNA sequences are modified from templated versions encoded in the genome. RNA editing is genetically and biochemically distinct from other RNA modifications such as splicing, capping, and polyadenylation although, as discussed in Section I, these modifications may have relevance to the regulation of certain types of mammalian RNA editing. This review will focus on C to U RNA editing, in particular, the biochemical and genetic mechanisms that regulate this process in mammals. These mechanisms will be examined in the context of the prototype model of C to U RNA editing, namely the posttranscriptional cytidine deamination targeting a single nucleotide in mammalian apolipoproteinB (apoB). Other examples of C to U RNA editing will be discussed and the molecular mechanisms-where known-contrasted with those regulating apoB RNA editing.
UR - http://www.scopus.com/inward/record.url?scp=1542570530&partnerID=8YFLogxK
U2 - 10.1016/S0079-6603(03)75001-6
DO - 10.1016/S0079-6603(03)75001-6
M3 - Chapter
C2 - 14604008
AN - SCOPUS:1542570530
SN - 0125400756
SN - 9780125400756
T3 - Progress in Nucleic Acid Research and Molecular Biology
SP - 1
EP - 41
BT - Progress in Nucleic Acid Research and Molecular Biology
PB - Academic Press Inc.
ER -