Molecular profiling of breast cancer

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Breast cancer is now considered a heterogeneous and phenotypically diverse disease. Molecular profiling is used in clinical practice in 2 broad categories: (1) characterization of breast cancers beyond the standard histopathologic features such as tumor grade, histologic subtype, and biomarker profile for prognostic information; and (2) prediction of response to therapy and clinical outcome. This article addresses the importance and application of molecular subtype analysis, and provides an in-depth analysis of the clinical application of the molecular prognostic indices for ductal carcinoma in situ, node-negative invasive breast cancer, and node-positive invasive breast cancer.

Original languageEnglish
Pages (from-to)451-462
Number of pages12
JournalSurgical Oncology Clinics of North America
Volume23
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Breast cancer
  • Genome
  • Molecular diagnostics
  • Molecular profiling
  • Prognostication

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