Molecular photoacoustic tomography with colloidal nanobeacons

Dipanjan Pan; Manojit Pramanik; Angana Senpan; Xinmai Yang; Kwang H. Song; Mike J. Scott; Huiying Zhang; Patrick J. Gaffney; Samuel A. Wickline; Lihong V. Wang; Gregory M. Lanza

doi:10.1002/anie.200805947

Molecular photoacoustic tomography with colloidal nanobeacons

Dipanjan Pan
, Manojit Pramanik
, Angana Senpan
, Xinmai Yang
, Kwang H. Song
, Mike J. Scott
, Huiying Zhang
, Patrick J. Gaffney
, Samuel A. Wickline
, Lihong V. Wang
, Gregory M. Lanza

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

Original language	English
Pages (from-to)	4170-4173
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	23
DOIs	https://doi.org/10.1002/anie.200805947
State	Published - May 25 2009

Keywords

Contrast agents
Gold
Molecular imaging
Nanoparticles
Photoacoustic tomography

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10.1002/anie.200805947

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title = "Molecular photoacoustic tomography with colloidal nanobeacons",

abstract = "Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.",

keywords = "Contrast agents, Gold, Molecular imaging, Nanoparticles, Photoacoustic tomography",

author = "Dipanjan Pan and Manojit Pramanik and Angana Senpan and Xinmai Yang and Song, \{Kwang H.\} and Scott, \{Mike J.\} and Huiying Zhang and Gaffney, \{Patrick J.\} and Wickline, \{Samuel A.\} and Wang, \{Lihong V.\} and Lanza, \{Gregory M.\}",

year = "2009",

month = may,

day = "25",

doi = "10.1002/anie.200805947",

language = "English",

volume = "48",

pages = "4170--4173",

journal = "Angewandte Chemie - International Edition",

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T1 - Molecular photoacoustic tomography with colloidal nanobeacons

AU - Pan, Dipanjan

AU - Pramanik, Manojit

AU - Senpan, Angana

AU - Yang, Xinmai

AU - Song, Kwang H.

AU - Scott, Mike J.

AU - Zhang, Huiying

AU - Gaffney, Patrick J.

AU - Wickline, Samuel A.

AU - Wang, Lihong V.

AU - Lanza, Gregory M.

PY - 2009/5/25

Y1 - 2009/5/25

N2 - Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

AB - Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

KW - Contrast agents

KW - Gold

KW - Molecular imaging

KW - Nanoparticles

KW - Photoacoustic tomography

UR - https://www.scopus.com/pages/publications/70349928776

U2 - 10.1002/anie.200805947

DO - 10.1002/anie.200805947

M3 - Article

C2 - 19418503

AN - SCOPUS:70349928776

SN - 1433-7851

VL - 48

SP - 4170

EP - 4173

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Molecular photoacoustic tomography with colloidal nanobeacons

Abstract

Keywords

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