Molecular photoacoustic tomography with colloidal nanobeacons

Dipanjan Pan, Manojit Pramanik, Angana Senpan, Xinmai Yang, Kwang H. Song, Mike J. Scott, Huiying Zhang, Patrick J. Gaffney, Samuel A. Wickline, Lihong V. Wang, Gregory M. Lanza

Research output: Contribution to journalArticle

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Abstract

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

Original languageEnglish
Pages (from-to)4170-4173
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number23
DOIs
StatePublished - May 25 2009

Keywords

  • Contrast agents
  • Gold
  • Molecular imaging
  • Nanoparticles
  • Photoacoustic tomography

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    Pan, D., Pramanik, M., Senpan, A., Yang, X., Song, K. H., Scott, M. J., Zhang, H., Gaffney, P. J., Wickline, S. A., Wang, L. V., & Lanza, G. M. (2009). Molecular photoacoustic tomography with colloidal nanobeacons. Angewandte Chemie - International Edition, 48(23), 4170-4173. https://doi.org/10.1002/anie.200805947