Molecular pathways and animal models of atrial septal defect

Patrick Y. Jay; Karl R. Degenhardt; Robert H. Anderson

doi:10.1007/978-3-7091-1883-2_21

Molecular pathways and animal models of atrial septal defect

Patrick Y. Jay, Karl R. Degenhardt, Robert H. Anderson

Division of Cardiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

The seeming simplicity of the clinical presentation and management of an atrial septal defect belies the complexity of the developmental pathogenesis. Here, we describe the anatomic development of the atrial septum and the venous return to the atrial chambers. Recent experimental results suggest where genetic mutations could disrupt developmental steps to cause a defect within the oval fossa, the so-called secundum defect or other interatrial communication, such as the sinus venosus defect.

Original language	English
Title of host publication	Congenital Heart Diseases
Subtitle of host publication	The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways
Publisher	Springer-Verlag Wien
Pages	291-300
Number of pages	10
ISBN (Electronic)	9783709118832
ISBN (Print)	9783709118825
DOIs	https://doi.org/10.1007/978-3-7091-1883-2_21
State	Published - Jan 1 2015

Keywords

ASD
Atrial septal defect
Atrial septation
Common atrium
Coronary sinus
Dorsal mesenchymal protrusion
Dorsal mesocardium
Down syndrome
Endocardial cushions
Endocardium
GATA4
Hox transcription factors
Knockout
MGRN1
Mesenchymal cap
NOS3
Ostium primum defect
Ostium secundum defect
Primary atrial foramen
Primary atrial septum
Second heart field
Sema3d
Semaphorin
Sinus venosus defect
TBX5
Vena cava

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10.1007/978-3-7091-1883-2_21

Cite this

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abstract = "The seeming simplicity of the clinical presentation and management of an atrial septal defect belies the complexity of the developmental pathogenesis. Here, we describe the anatomic development of the atrial septum and the venous return to the atrial chambers. Recent experimental results suggest where genetic mutations could disrupt developmental steps to cause a defect within the oval fossa, the so-called secundum defect or other interatrial communication, such as the sinus venosus defect.",

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Molecular pathways and animal models of atrial septal defect

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Keywords

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