Molecular pathology of myeloproliferative neoplasms

Jeffery M. Klco, Ravi Vij, Friederike H. Kreisel, Anjum Hassan, John L. Frater

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Myeloproliferative neoplasms (MPNs; formerly chronic myeloproliferative disorders) are a class of myeloid hematologic malignancies that represent a stem cell-derived expansion of 1 or more hematopoietic cell lineages. The current 2008 World Health Organization system recognizes 8 types of MPN: chronic myelogenous leukemia, chronic neutrophilic leukemia, polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic eosinophilic leukemia, mastocytosis, and myeloproliferative neoplasm, unclassifiable. This review summarizes the salient characteristics of the MPNs, with emphasis on recent developments in the molecular pathophysiology and therapeutic monitoring of these disorders.

Original languageEnglish
Pages (from-to)602-615
Number of pages14
JournalAmerican journal of clinical pathology
Volume133
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Chronic eosinophilic leukemia
  • Chronic myelogenous leukemia
  • Chronic neutrophilic leukemia
  • Essential thrombocythemia
  • Mastocytosis
  • Molecular pathology
  • Myeloproliferative neoplasm
  • Myeloproliferative neoplasms
  • Polycythemia vera
  • Primary myelofibrosis
  • Unclassifiable

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