Molecular pathology of myeloproliferative neoplasms

Jeffery M. Klco, Ravi Vij, Friederike H. Kreisel, Anjum Hassan, John L. Frater

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Myeloproliferative neoplasms (MPNs; formerly chronic myeloproliferative disorders) are a class of myeloid hematologic malignancies that represent a stem cell-derived expansion of 1 or more hematopoietic cell lineages. The current 2008 World Health Organization system recognizes 8 types of MPN: chronic myelogenous leukemia, chronic neutrophilic leukemia, polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic eosinophilic leukemia, mastocytosis, and myeloproliferative neoplasm, unclassifiable. This review summarizes the salient characteristics of the MPNs, with emphasis on recent developments in the molecular pathophysiology and therapeutic monitoring of these disorders.

Original languageEnglish
Pages (from-to)602-615
Number of pages14
JournalAmerican journal of clinical pathology
Issue number4
StatePublished - Apr 2010


  • Chronic eosinophilic leukemia
  • Chronic myelogenous leukemia
  • Chronic neutrophilic leukemia
  • Essential thrombocythemia
  • Mastocytosis
  • Molecular pathology
  • Myeloproliferative neoplasm
  • Myeloproliferative neoplasms
  • Polycythemia vera
  • Primary myelofibrosis
  • Unclassifiable


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