Molecular mechanisms that limit the costs of NLR-mediated resistance in plants

Manon M.S. Richard, Ariane Gratias, Blake C. Meyers, Valérie Geffroy

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Crop diseases cause significant yield losses, and the use of resistant cultivars can effectively mitigate these losses and control many plant diseases. Most plant resistance (R) genes encode immune receptors composed of nucleotide-binding and leucine-rich repeat (NLR) domains. These proteins mediate the specific recognition of pathogen avirulence effectors to induce defence responses. However, NLR-triggered immunity can be associated with a reduction in growth and yield, so-called ‘fitness costs’. Recent data have shown that plants use an elaborate interplay of different mechanisms to control NLR gene transcript levels, as well as NLR protein abundance and activity, to avoid the associated cost of resistance in the absence of a pathogen. In this review, we discuss the different levels of NLR regulation (transcriptional, post-transcriptional and at the protein level). We address the apparent need for plants to maintain diverse modes of regulation. A recent model suggesting an equilibrium ‘ON/OFF state’ of NLR proteins, in the absence of a pathogen, provides the context for our discussion.

Original languageEnglish
Pages (from-to)2516-2523
Number of pages8
JournalMolecular Plant Pathology
Issue number11
StatePublished - Nov 2018


  • cost
  • methylation
  • plant disease resistance genes
  • post-transcriptional regulation
  • small RNAs
  • transcriptional regulation


Dive into the research topics of 'Molecular mechanisms that limit the costs of NLR-mediated resistance in plants'. Together they form a unique fingerprint.

Cite this