Molecular mechanisms of viral inhibitors of RIG-I-like receptors

Daisy W. Leung; Christopher F. Basler; Gaya K. Amarasinghe

doi:10.1016/j.tim.2011.12.005

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest that several virus-encoded components that antagonize RLR signaling interact with and inhibit the interferon (IFN)-α/β activation pathway using both RNA-dependent and RNA-independent mechanisms. The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional nature of viral RLR antagonists, is reviewed in the context of recent biochemical and structural studies.

Original language	English
Pages (from-to)	139-146
Number of pages	8
Journal	Trends in Microbiology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.tim.2011.12.005
State	Published - Mar 2012

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title = "Molecular mechanisms of viral inhibitors of RIG-I-like receptors",

abstract = "Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest that several virus-encoded components that antagonize RLR signaling interact with and inhibit the interferon (IFN)-α/β activation pathway using both RNA-dependent and RNA-independent mechanisms. The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional nature of viral RLR antagonists, is reviewed in the context of recent biochemical and structural studies.",

author = "Leung, {Daisy W.} and Basler, {Christopher F.} and Amarasinghe, {Gaya K.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported by the National Institutes of Health [grant 1R56AI089547 to C.F.B. and G.K.A. grant 1F32AI084324 to D.W.L. grants R01AI059536 and AI057158 (Northeast Biodefense Center-Lipkin) to C.F.B. and grant R01AI081914 to G.K.A.], a Midwest Regional Center of Excellence (MRCE) developmental grant (grant U54AI057160-Virgin to G.K.A.).",

year = "2012",

month = mar,

doi = "10.1016/j.tim.2011.12.005",

language = "English",

volume = "20",

pages = "139--146",

journal = "Trends in Microbiology",

issn = "0966-842X",

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T1 - Molecular mechanisms of viral inhibitors of RIG-I-like receptors

AU - Leung, Daisy W.

AU - Basler, Christopher F.

AU - Amarasinghe, Gaya K.

N1 - Funding Information: Work in the authors’ laboratories is supported by the National Institutes of Health [grant 1R56AI089547 to C.F.B. and G.K.A. grant 1F32AI084324 to D.W.L. grants R01AI059536 and AI057158 (Northeast Biodefense Center-Lipkin) to C.F.B. and grant R01AI081914 to G.K.A.], a Midwest Regional Center of Excellence (MRCE) developmental grant (grant U54AI057160-Virgin to G.K.A.).

PY - 2012/3

Y1 - 2012/3

N2 - Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest that several virus-encoded components that antagonize RLR signaling interact with and inhibit the interferon (IFN)-α/β activation pathway using both RNA-dependent and RNA-independent mechanisms. The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional nature of viral RLR antagonists, is reviewed in the context of recent biochemical and structural studies.

AB - Activation of innate immune signaling pathways through cytosolic RIG-I-like receptors (RLR) is a crucial response that is antagonized by many viruses. A variety of RNA-related pathogen-associated molecular patterns (PAMPS) have been identified and their role in RLR activation has been examined. Recent studies suggest that several virus-encoded components that antagonize RLR signaling interact with and inhibit the interferon (IFN)-α/β activation pathway using both RNA-dependent and RNA-independent mechanisms. The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional nature of viral RLR antagonists, is reviewed in the context of recent biochemical and structural studies.

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U2 - 10.1016/j.tim.2011.12.005

DO - 10.1016/j.tim.2011.12.005

M3 - Review article

C2 - 22325030

AN - SCOPUS:84857995280

SN - 0966-842X

VL - 20

SP - 139

EP - 146

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 3

ER -

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

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