TY - JOUR
T1 - Molecular mechanisms of synaptic vesicle docking and membrane fusion
AU - Wendland, Beverly
AU - Scheller, Richard H.
PY - 1994
Y1 - 1994
N2 - Studies of the interactions between synaptic proteins are revealing the molecular mechanisms of synaptic vesicle docking and membrane fusion. A 7S complex between the synaptic vesicle proteins synaptotagmin and VAMP, and the plasma membrane proteins syntaxin and SNAP-25 is thought to initiate the docking of vesicles. This is followed by recruitment of the soluble factors α-SNAP and the NSF ATPase to form a ~ 20S particle. The hydrolysis of ATP is required for the disassembly of the complex and may ultimately result in the fusion of the membranes. Sequence similarities between syntaxin and neurexins are presented, and a possible role for neurexins in alternative complexes is suggested.
AB - Studies of the interactions between synaptic proteins are revealing the molecular mechanisms of synaptic vesicle docking and membrane fusion. A 7S complex between the synaptic vesicle proteins synaptotagmin and VAMP, and the plasma membrane proteins syntaxin and SNAP-25 is thought to initiate the docking of vesicles. This is followed by recruitment of the soluble factors α-SNAP and the NSF ATPase to form a ~ 20S particle. The hydrolysis of ATP is required for the disassembly of the complex and may ultimately result in the fusion of the membranes. Sequence similarities between syntaxin and neurexins are presented, and a possible role for neurexins in alternative complexes is suggested.
KW - Exocytosis
KW - Membrane fusion
KW - Membrane trafficking
KW - Synaptic transmission
KW - Vesicles
UR - https://www.scopus.com/pages/publications/0028284132
U2 - 10.1006/smns.1994.1022
DO - 10.1006/smns.1994.1022
M3 - Article
AN - SCOPUS:0028284132
SN - 1044-5765
VL - 6
SP - 167
EP - 176
JO - Seminars in the Neurosciences
JF - Seminars in the Neurosciences
IS - 3
ER -