Molecular mechanisms of IgE regulation

L. B. Bacharier; R. S. Geha

doi:10.1016/s0091-6749(00)90059-9

Molecular mechanisms of IgE regulation

L. B. Bacharier, R. S. Geha

Division of Allergy & Pulmonary Medicine

Research output: Contribution to journal › Review article › peer-review

179 Scopus citations

Abstract

IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cε gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

Original language	English
Pages (from-to)	S547-S558
Journal	Journal of Allergy and Clinical Immunology
Volume	105
Issue number	2 II
DOIs	https://doi.org/10.1016/s0091-6749(00)90059-9
State	Published - 2000

Keywords

IgE
Interleukins
Isotype switching

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10.1016/s0091-6749(00)90059-9

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title = "Molecular mechanisms of IgE regulation",

abstract = "IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cε gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.",

keywords = "IgE, Interleukins, Isotype switching",

author = "Bacharier, {L. B.} and Geha, {R. S.}",

note = "Funding Information: Supported by NIH grants AI-31136, AI-35714, AI-31541, T32 (Training Grant) AI-07512, and by grants from Baxter, Alpha Therapeutics, and Olsten Corporations. ",

year = "2000",

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AU - Bacharier, L. B.

AU - Geha, R. S.

N1 - Funding Information: Supported by NIH grants AI-31136, AI-35714, AI-31541, T32 (Training Grant) AI-07512, and by grants from Baxter, Alpha Therapeutics, and Olsten Corporations.

PY - 2000

Y1 - 2000

N2 - IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cε gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

AB - IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cε gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

KW - IgE

KW - Interleukins

KW - Isotype switching

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U2 - 10.1016/s0091-6749(00)90059-9

DO - 10.1016/s0091-6749(00)90059-9

M3 - Review article

C2 - 10669540

AN - SCOPUS:0033983006

SN - 0091-6749

VL - 105

SP - S547-S558

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2 II

ER -

Molecular mechanisms of IgE regulation

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Keywords

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