Molecular mechanisms of IgE regulation

L. B. Bacharier, R. S. Geha

Research output: Contribution to journalReview articlepeer-review

175 Scopus citations


IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cε gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.

Original languageEnglish
Pages (from-to)S547-S558
JournalJournal of Allergy and Clinical Immunology
Issue number2 II
StatePublished - 2000


  • IgE
  • Interleukins
  • Isotype switching


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