Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalMicrobes and Infection
Issue number2
StatePublished - Feb 2010


  • Enterotoxigenic Escherichia coli
  • Enterotoxins
  • Escherichia coli vaccines
  • Genomics
  • Pathogenesis


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