Molecular mechanisms of enterotoxigenic Escherichia coli infection

James M. Fleckenstein, Philip R. Hardwidge, George P. Munson, David A. Rasko, Halvor Sommerfelt, Hans Steinsland

Research output: Contribution to journalShort survey

175 Scopus citations

Abstract

Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalMicrobes and Infection
Volume12
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Keywords

  • Enterotoxigenic Escherichia coli
  • Enterotoxins
  • Escherichia coli vaccines
  • Genomics
  • Pathogenesis

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  • Cite this

    Fleckenstein, J. M., Hardwidge, P. R., Munson, G. P., Rasko, D. A., Sommerfelt, H., & Steinsland, H. (2010). Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes and Infection, 12(2), 89-98. https://doi.org/10.1016/j.micinf.2009.10.002