TY - JOUR
T1 - Molecular mechanism of long-chain fatty acid uptake
AU - Schaffer, Jean E.
AU - Lodish, Harvey F.
N1 - Funding Information:
We thank R. Wells for critical review of this manuscript. J.E.S. is supported by a National Institutes of Health Physician Scientist Award (HL02696). Support for this work was also provided by a Program of Excellence in Molecular Biology grant from the National Heart, Lung, and Blood Institute (HL41484).
PY - 1995
Y1 - 1995
N2 - Most eukaryotic cells are capable of taking up long-chain fatty acids (LCFAs) to be used for a variety of cellular processes. Low levels of cellular uptake may occur by simple diffusion of these hydrophobic molecules through the plasma membrane. However, tissues such as cardiac muscle and fat specifically and efficiently take up and release LCFAs in a regulated fashion. In cardiac myocytes and adipocytes, a recently described integral plasma membrane fatty acid transport protein (FATP) functions as an LCFA transporter. FATP may play a role in abnormalities o f LCFA uptake and metabolism in cardiac pathophysiology.
AB - Most eukaryotic cells are capable of taking up long-chain fatty acids (LCFAs) to be used for a variety of cellular processes. Low levels of cellular uptake may occur by simple diffusion of these hydrophobic molecules through the plasma membrane. However, tissues such as cardiac muscle and fat specifically and efficiently take up and release LCFAs in a regulated fashion. In cardiac myocytes and adipocytes, a recently described integral plasma membrane fatty acid transport protein (FATP) functions as an LCFA transporter. FATP may play a role in abnormalities o f LCFA uptake and metabolism in cardiac pathophysiology.
UR - https://www.scopus.com/pages/publications/0029569058
U2 - 10.1016/1050-1738(95)00102-6
DO - 10.1016/1050-1738(95)00102-6
M3 - Review article
C2 - 21232263
AN - SCOPUS:0029569058
SN - 1050-1738
VL - 5
SP - 218
EP - 224
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 6
ER -