Molecular imaging using a site-targeted ultrasound contrast agent

Jon N. Marsh, Christopher S. Hall, Dana R. Abendschein, David E. Scherrer, Michael J. Scott, Ralph J. Fuhrhop, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


We have developed a nongaseous, ligand-targeted perfluorocarbon nanoparticle emulsion which can acoustically enhance the presence of molecular epitopes on tissue surfaces. In a two-part study, we first demonstrate how perfluorocarbons with varying phase velocities impact the acoustic reflectivity of plasma clots targeted with an anti-fibrin perfluorocarbon nanoparticle in vitro. The targeted perfluorocarbon contrast agents increased backscattered power from 18.2 to 23.4 dB with the greatest enhancement noted for formulations with low acoustic impedance. Porcine carotid arteries were injured by percutaneous balloon angioplasty and treated in situ with a tissue factor-targeted or control nanoparticulate immunoemulsion. Intravascular ultrasound images (30 MHz) of the arteries before and after application of contrast agent demonstrated the acoustic localization and enhancement of stretch-induced tissue factor expression within the carotid media, which was not apparent in the control vessels.

Original languageEnglish
Pages (from-to)1713-1716
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
StatePublished - 1999
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999


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