Molecular Imaging for Radiotherapy Planning and Response Assessment for Cervical Cancer

Alexander J. Lin; Farrokh Dehdashti; Perry W. Grigsby

doi:10.1053/j.semnuclmed.2019.06.009

Molecular Imaging for Radiotherapy Planning and Response Assessment for Cervical Cancer

Alexander J. Lin, Farrokh Dehdashti, Perry W. Grigsby

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Positron emission tomography (PET) with [¹⁸F]fluorodeoxyglucose (FDG) leverages imaging contrast from accelerated and aberrant glucose metabolism, which is a hallmark of cancer. FDG-PET is essential for assessing involved lymph nodes and distant metastases for cervical cancer. It is also utilized for target delineation in radiation treatment planning, with investigations into functional bone marrow sparing intensity modulated radiation therapy. Tumor heterogeneity in FDG-uptake is part of a radiomics approach to potentially escalate treatment to radiation-resistant tumors. Standardizing posttreatment PET surveillance could also allow early surgical salvage of recurrent tumors. The future of molecular imaging in cervical cancer will require development of novel PET tracers to personalize treatments based on tumor biology.

Original language	English
Pages (from-to)	493-500
Number of pages	8
Journal	Seminars in Nuclear Medicine
Volume	49
Issue number	6
DOIs	https://doi.org/10.1053/j.semnuclmed.2019.06.009
State	Published - Nov 2019

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title = "Molecular Imaging for Radiotherapy Planning and Response Assessment for Cervical Cancer",

abstract = "Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) leverages imaging contrast from accelerated and aberrant glucose metabolism, which is a hallmark of cancer. FDG-PET is essential for assessing involved lymph nodes and distant metastases for cervical cancer. It is also utilized for target delineation in radiation treatment planning, with investigations into functional bone marrow sparing intensity modulated radiation therapy. Tumor heterogeneity in FDG-uptake is part of a radiomics approach to potentially escalate treatment to radiation-resistant tumors. Standardizing posttreatment PET surveillance could also allow early surgical salvage of recurrent tumors. The future of molecular imaging in cervical cancer will require development of novel PET tracers to personalize treatments based on tumor biology.",

author = "Lin, {Alexander J.} and Farrokh Dehdashti and Grigsby, {Perry W.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

doi = "10.1053/j.semnuclmed.2019.06.009",

language = "English",

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pages = "493--500",

journal = "Seminars in Nuclear Medicine",

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AU - Lin, Alexander J.

AU - Dehdashti, Farrokh

AU - Grigsby, Perry W.

PY - 2019/11

Y1 - 2019/11

N2 - Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) leverages imaging contrast from accelerated and aberrant glucose metabolism, which is a hallmark of cancer. FDG-PET is essential for assessing involved lymph nodes and distant metastases for cervical cancer. It is also utilized for target delineation in radiation treatment planning, with investigations into functional bone marrow sparing intensity modulated radiation therapy. Tumor heterogeneity in FDG-uptake is part of a radiomics approach to potentially escalate treatment to radiation-resistant tumors. Standardizing posttreatment PET surveillance could also allow early surgical salvage of recurrent tumors. The future of molecular imaging in cervical cancer will require development of novel PET tracers to personalize treatments based on tumor biology.

AB - Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) leverages imaging contrast from accelerated and aberrant glucose metabolism, which is a hallmark of cancer. FDG-PET is essential for assessing involved lymph nodes and distant metastases for cervical cancer. It is also utilized for target delineation in radiation treatment planning, with investigations into functional bone marrow sparing intensity modulated radiation therapy. Tumor heterogeneity in FDG-uptake is part of a radiomics approach to potentially escalate treatment to radiation-resistant tumors. Standardizing posttreatment PET surveillance could also allow early surgical salvage of recurrent tumors. The future of molecular imaging in cervical cancer will require development of novel PET tracers to personalize treatments based on tumor biology.

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DO - 10.1053/j.semnuclmed.2019.06.009

M3 - Review article

C2 - 31630733

AN - SCOPUS:85067271245

SN - 0001-2998

VL - 49

SP - 493

EP - 500

JO - Seminars in Nuclear Medicine

JF - Seminars in Nuclear Medicine

IS - 6

ER -

Molecular Imaging for Radiotherapy Planning and Response Assessment for Cervical Cancer

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