Molecular imaging by cardiovascular MR

Tillmann Cyrus, Gregory M. Lanza, Samuel A. Wickline

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Do molecularly-targeted contrast agents have what it takes to usher in a paradigm shift as to how we will image cardiovascular disease in the near future? Moreover, are non-invasive vulnerable plaque detection and preemptive treatments with these novel nanoparticulate agents within reach for clinical applications? In this article, we attempt to make a compelling case for how the advent of molecularly-targeted nanoparticle technology may change the way we detect atherosclerotic lesions, determine their clinical significance and even provide non-invasive treatments. Focusing on imaging with cardiovascular MR, an overview of the latest developments in this rapidly evolving field of so-called "intelligent" contrast agents that are able to interrogate the vascular wall and various complementary advanced imaging technologies are presented.

Original languageEnglish
Pages (from-to)827-843
Number of pages17
JournalJournal of Cardiovascular Magnetic Resonance
Volume9
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Atherosclerosis
  • Contrast Agent
  • MRI
  • Molecular Targeting
  • Nanoparticle
  • Vulnerable Plaque

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