Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

Samuel A. Wickline, Anne M. Neubauer, Patrick M. Winter, Shelton D. Caruthers, Gregory M. Lanza

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations

Abstract

Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.

Original languageEnglish
Pages (from-to)667-680
Number of pages14
JournalJournal of Magnetic Resonance Imaging
Volume25
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Atherosclerosis
  • Contrast agents
  • Drug therapy
  • Imaging
  • Nanotechnology

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