Molecular heterogeneity of c2 deficiency

Charles A. Johnson, Rick A. Wetsel, Harvey R. Colten, F. Sessions Cole, Peter Densen, Nancy E. Goeken

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The most common of the complement deficiencies in populations of European origin is a genetic deficiency of the second component of complement (C2).1 Rheumatologic disorders such as systemic lupus erythematosus, Henoch—Schönlein purpura, and polymyositis have been recognized in more than half the patients with this deficiency. To a lesser extent, C2 deficiency has been associated with increased susceptibility to infection.2 Genes encoding the proteins C2 and C4 (the fourth component of complement) of the classic complement-activation pathway and factor B of the alternative pathway are located in the major histocompatibility complex (MHC) on the short arm of chromosome 6 between.

Original languageEnglish
Pages (from-to)871-874
Number of pages4
JournalNew England Journal of Medicine
Issue number13
StatePublished - Mar 26 1992

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