Molecular Genetics of Cataract

Alan Shiels, J. Fielding Hejtmancik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

34 Scopus citations

Abstract

Lens opacities or cataract(s) represent a universally important cause of visual impairment and blindness. Typically, cataract is acquired with aging as a complex disorder involving environmental and genetic risk factors. Cataract may also be inherited with an early onset either in association with other ocular and/or systemic abnormalities or as an isolated lens phenotype. Here we briefly review recent advances in gene discovery for inherited and age-related forms of cataract that are providing new insights into lens development and aging.

Original languageEnglish
Title of host publicationMolecular Biology of Eye Disease, 2015
EditorsJohn M. Nickerson, J. Fielding Hejtmancik
PublisherElsevier B.V.
Pages203-218
Number of pages16
ISBN (Print)9780128010594
DOIs
StatePublished - Jan 1 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume134
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Age-related
  • Cataract
  • Genes
  • Inherited

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    Shiels, A., & Hejtmancik, J. F. (2015). Molecular Genetics of Cataract. In J. M. Nickerson, & J. F. Hejtmancik (Eds.), Molecular Biology of Eye Disease, 2015 (pp. 203-218). (Progress in Molecular Biology and Translational Science; Vol. 134). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2015.05.004