Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

Qin Liu, Sophia Vrontou, Frank L. Rice, Mark J. Zylka, Xinzhong Dong, David J. Anderson

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

C-fiber tactile afferents are a subpopulation of unmyelinated cutaneous sensory neurons activated by gentle stroking. Using a genetically encoded tracer, we found that Mas-related G protein-coupled receptor B4 marks a rare subpopulation of unmyelinated, nonpeptidergic sensory fibers that exclusively innervate hairy skin. These fibers terminate in large arborizations similar in size and distribution to C-fiber tactile afferent receptive fields, suggesting that MrgprB4 may provide genetic access to these elusive neurons in mice.

Original languageEnglish
Pages (from-to)946-948
Number of pages3
JournalNature neuroscience
Volume10
Issue number8
DOIs
StatePublished - Aug 2007

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