Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules

J. C. Ryan, J. Turck, E. C. Niemi, W. M. Yokoyama, W. E. Seaman

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands.

Original languageEnglish
Pages (from-to)1631-1635
Number of pages5
JournalJournal of Immunology
Volume149
Issue number5
StatePublished - 1992

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