TY - JOUR
T1 - Molecular cloning of a novel laminin chain, α5, and widespread expression in adult mouse tissues
AU - Miner, J. H.
AU - Lewis, R. M.
AU - Sanes, J. R.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - We have identified a fifth member of the α subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of α5 to the only known Drosophila α chain, suggesting that the ancestral α gene was more similar to α5 than to α1-4. Analysis of RNA expression showed that α5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that α5 may be a major laminin chain of adult basal laminae.
AB - We have identified a fifth member of the α subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of α5 to the only known Drosophila α chain, suggesting that the ancestral α gene was more similar to α5 than to α1-4. Analysis of RNA expression showed that α5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that α5 may be a major laminin chain of adult basal laminae.
UR - http://www.scopus.com/inward/record.url?scp=0028860732&partnerID=8YFLogxK
U2 - 10.1074/jbc.270.48.28523
DO - 10.1074/jbc.270.48.28523
M3 - Article
C2 - 7499364
AN - SCOPUS:0028860732
SN - 0021-9258
VL - 270
SP - 28523
EP - 28526
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 48
ER -